生物活性：Pimozide-d5 N-Oxide is the deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5[1][2].
IC50 & Target：D1 Receptor
D3 Receptor
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Pimozide-d5 N-Oxide 相关抗体:
FOXP3 Antibody (YA858)
Phospho-STAT3 (Tyr705) Antibody (YA146)
STAT3 Antibody (YA056)
Phospho-STAT1 (Ser727) Antibody (YA148)
Phospho-STAT1 (Tyr701) Antibody
Phospho-STAT3 (Tyr705) Antibody
FOXP3 Antibody
Phospho-STAT3 (Ser727) Antibody
STAT1 Antibody (YA059)
STAT1 Antibody (YA667)
STAT1 alpha Antibody
STAT2 Antibody (YA057)
STAT5a Antibody
STAT5b Antibody
STAT6 Antibody
Phospho-STAT5 (Tyr694) Antibody (YA145)
FOXP3 Antibody (YA759)
Phospho-STAT1 (Ser727) Antibody (YA149)
STAT3 Antibody (YA666)
STAT4 Antibody
STAT5 Antibody
ADRB2 Antibody
DRD2 Antibody
Phospho-STAT5(Tyr694) Antibody (YA1513)
Dopamine Receptor D3 Antibody (YA1742)
DOPA Decarboxylase Antibody (YA2428)
Dopamine Receptor D1 Antibody (YA3270)
Salbutamol Antibody (YA901)
Clenbuterol Antibody (YA904)
T-bet / Tbx21 Antibody (YA1217)
分子量：482.58
Formula：C28H24D5F2N3O2
CAS 号：1794795-40-6
非标记 CAS：2062-78-4
中文名称：匹莫齐特 d5（N 氧化物）
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (533 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
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[2]. Ybema CE, et al. Adrenoceptors and dopamine receptors are not involved in the discriminative stimulus effect of the 5-HT1A receptor agonist flesinoxan. Eur J Pharmacol. 1994 Apr 21;256(2):141-7.
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[3]. Cai N, et al. The STAT3 inhibitor pimozide impedes cell proliferation and induces ROS generation in human osteosarcoma by suppressing catalase expression. Am J Transl Res. 2017 Aug 15;9(8):3853-3866. eCollection 2017.
 [Content Brief]
[4]. Erik A. Nelson, et al. The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors. Blood. 2011 Mar 24; 117(12): 3421-3429.
 [Content Brief]