生物活性：Lubiprostone-d7 (RU-0211-d7) is the deuterium labeled Lubiprostone. Lubiprostone (SPI-0211) increases intestinal fluid secretion through generation of CIC-2/CFTR and activation of cAMP signaling pathway. Lubiprostone inhibits myeloperoxidase (MPO) activity, downregulates Indomethacin (HY-14397)-induced iNOS and TNFα expression. Lubiprostone can be used for chronic constipation research[1][2][3].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Lubiprostone-d7 相关抗体:
GPX4 Antibody
iNOS Antibody
TNF alpha Antibody
Glutathione Peroxidase 4 Antibody
TNF Receptor 2 Antibody
CD40 Antibody
CD40L Antibody
DR5 Antibody
GPX1 Antibody
nNOS Antibody
Glutathione Peroxidase 1 Antibody (YA404)
Calumenin Antibody (YA813)
eNOS Antibody
Phospho-eNOS (Ser1177) Antibody
MPO Antibody
DDAH2 Antibody (YA1447)
TNFAIP3 Antibody (YA2231)
TRADD Antibody (YA2276)
DcR2 Antibody (YA2588)
TNFRSF10B Antibody (YA660)
Anoctamin 1 Antibody
4-1BB Ligand Antibody (YA1329)
GITR Antibody (YA1333)
BAFFR Antibody (YA1356)
BCMA Antibody (YA1501)
4-1BB Antibody (YA1506)
TNFSF12 Antibody (YA1507)
BAFF Antibody (YA1510)
LIGHT Antibody (YA1512)
GITR-L Antibody (YA1515)
分子量：397.51
Formula：C20H25D7F2O5
CAS 号：1217675-13-2
非标记 CAS：136790-76-6
中文名称：鲁比前列酮 d7
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (534 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
 [Content Brief]
[2]. http://en.wikipedia.org/wiki/Lubiprostone