生物活性：Pravastatin-d3 (sodium) is the deuterium labeled Pravastatin sodium salt. Pravastatin (CS-514) sodium salt is a competitive HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM[1][2].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Pravastatin-d3 sodium 相关抗体:
HMGCS2 Antibody
HMGB1 Antibody
HMGCR Antibody
Baf180 Antibody (YA1176)
BANF1 Antibody (YA1740)
LEF1 Antibody (YA3164)
HMGA1 Antibody (YA1185)
HMGA2 Antibody (YA1186)
Baf57 Antibody (YA2110)
HMGN2 Antibody (YA2839)
HMG4 Antibody (YA2992)
HMGB2 Antibody (YA2995)
HMGCL Antibody (YA3024)
分子量：449.53
Formula：C23H32D3NaO7
CAS 号：1329836-90-9
非标记 CAS：81131-70-6
性状：固体
颜色：White to off-white
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Store at room temperature, keep dry and cool
In solvent：-80°C：2 years
-20°C：1 year
纯度 & 产品资料
纯度： 99.02%
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
 [Content Brief]
[2]. McTavish D, et al. Pravastatin. A review of its pharmacological properties and therapeutic potential in hypercholesterolaemia. Drugs. 1991 Jul;42(1):65-89.
 [Content Brief]