生物活性：Brexpiprazole S-oxide-d8 is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM[1][2][3].
IC50 & Target[2]
5-HT1A Receptor
0.12 nM (Ki)
5-HT2A Receptor
0.47 nM (Ki)
D2 Receptor
0.3 nM (Ki)
分子量：457.61
Formula：C25H19D8N3O3S
CAS 号：2748605-29-8
非标记 CAS：1191900-51-2
性状：固体
颜色：White to off-white
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Powder：-20°C：3 years，4°C：2 years
In solvent：-80°C：6 months，-20°C：1 month