生物活性：Amitriptyline-d6 (hydrochloride) is the deuterium labeled Amitriptyline hydrochloride. Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity[1][2][3].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Amitriptyline-d6 hydrochloride 相关抗体:
TrkA Antibody
ADGRE1 (F4/80) Antibody (YA002)
xCT Antibody (YA006)
TrkB Antibody
xCT Antibody (YA652)
BDNF Antibody
Phospho-TrkA/B (Tyr490/Tyr516) Antibody
Trk B Antibody
ADGRE1 (F4/80) Antibody (YA920)
ADRB2 Antibody
MTNR1A Antibody
NGF Antibody
Alpha-ENaC Antibody
p75 NGF Receptor Antibody (YA1245)
Serotonin Transporter Antibody (YA1638)
HTR7 Antibody (YA2796)
HTR2C Antibody (YA3364)
CRMP2 Antibody (YA3370)
TrkA+B+C Antibody
Salbutamol Antibody (YA901)
Clenbuterol Antibody (YA904)
Muscarinic Acetylcholine receptor M3 Antibody
SLC12A1 Antibody (YA1403)
Trk A Antibody (YA1489)
CRMP1 Antibody (YA1941)
alpha 1a Adrenergic Receptor Antibody (YA2059)
CRMP5 Antibody (YA2497)
CRMP3 Antibody (YA2563)
Muscarinic Acetylcholine Receptor M2 Antibody (YA2610)
CRMP4 Antibody (YA2777)
分子量：319.90
Formula：C20H18D6ClN
CAS 号：203645-63-0
非标记 CAS：549-18-8
性状：固体
颜色：White to off-white
中文名称：盐酸阿米替林 d6 (盐酸盐)
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：4°C, sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)