生物活性：Flufenamic acid-13C6 is the 13C6 labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca2+ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Flufenamic acid-13C6 相关抗体:
Annexin VI Antibody
AMPK alpha Antibody
Phospho-AMPK alpha 2 (Thr172) Antibody
COX2 Antibody
AMPK alpha 2 Antibody (YA833)
Phospho-AMPK alpha 2(Ser345) Antibody
AMPK alpha 1 Antibody
Calbindin Antibody
Calreticulin Antibody
COX IV Antibody
COX2/Cyclooxygenase 2 Antibody
AMPK alpha 1 Antibody (YA624)
Phospho-AMPK alpha 1 (Ser496) Antibody (YA226)
Phospho-Hormone sensitive lipase (Ser853) Antibody
ATF4 Antibody (YA605)
ATP1A1 Antibody
AMPK alpha 2 Antibody (YA623)
AMPK beta 1 Antibody
AMPK gamma 1 Antibody
ATF4 Antibody
Phospho-AMPK alpha 1 (Ser496) Antibody
COX IV Antibody (YA867)
Cardiac Troponin I/TNNC1 Antibody
SCGN Antibody (YA1167)
RAMP1 Antibody (YA1818)
Annexin V Antibody (YA1829)
Striatin 4 Antibody (YA2088)
Fibulin 5 Antibody (YA2448)
Cyclooxygenase 1 Antibody (YA2537)
Cyclooxygenase 2 Antibody (YA2541)
分子量：287.19
Formula：C813C6H10F3NO2
CAS 号：1325559-30-5
非标记 CAS：530-78-9
性状：固体
颜色：White to off-white
中文名称：氟芬那酸-13C6； 氟灭酸-13C6
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Powder：-20°C：3 years
In solvent：-80°C：6 months，-20°C：1 month
纯度 & 产品资料
纯度： 99.5%
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
 [Content Brief]
[2]. Guinamard R, et al. Flufenamic acid as an ion channel modulator. Pharmacol Ther. 2013 May;138(2):272-84.
 [Content Brief]
[3]. Pongkorpsakol P, et al. Flufenamic acid protects against intestinal fluid secretion and barrier leakage in a mouse model of Vibrio cholerae infection through NF-κB inhibition and AMPK activation. Eur J Pharmacol. 2017 Mar 5;798:94-104.
 [Content Brief]
[4]. Pongkorpsakol P, et al. Cellular mechanisms underlying the inhibitory effect of flufenamic acid on chloride secretion in human intestinal epithelial cells. J Pharmacol Sci. 2017 Jun;134(2):93-100.
 [Content Brief]
[5]. Pobbati AV, et al. Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy. Structure. 2015;23(11):2076-2086.
 [Content Brief]