Name:Ginsenoside Rd
Synonyms:Panaxoside Rd, Sanchinoside Rd
CAS Number:52705-93-8
Formula:C48H82O18
M.w.:947.15
DMSO (mg/mL)Max Solubility:90
DMSO (mM)Max Solubility:95.02
Form:free base
SMILES:CC(C)=CCCC(C)(OC1OC(CO)C(O)C(O)C1O)C2CCC3(C)C2C(O)CC4C5(C)CCC(OC6OC(CO)C(O)C(O)C6OC7OC(CO)C(O)C(O)C7O)C(C)(C)C5CCC34C
ALogP:0.548
Target:Calcium Channel,COX,NF-κB,NOS,P450 (e.g. CYP17)
Pathway:Immunology & Inflammation
Information:Ginsenoside Rd (Panaxoside Rd, Sanchinoside Rd), a minor ginseng saponin, has several pharmacological activities such as immunosuppressive activity, anti-inflammatory activity, immunological adjuvant, anti-cancer activity and wound-healing activity. Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional activity with an IC50 of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside Rd inhibits CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC50s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively.
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