Name:PF-04995274
Synonyms:PF-4995274
CAS Number:1331782-27-4
Formula:C23H32N2O6
M.w.:432.51
DMSO (mg/mL)Max Solubility:86
DMSO (mM)Max Solubility:198.84
Form:Free Base
SMILES:OC1(CCOCC1)CN2CCC(CC2)COC3=NOC4=C3C(=CC=C4)OC5CCOC5
ALogP:1.615
Target:5-HT Receptor
Pathway:Neuronal Signaling
Information:PF-04995274 (PF-4995274) is a potent, high-affinity, orally active and partial agonist of serotonin 4 receptor (5-HT4R) with EC50 of 0.47 nM, 0.36 nM, 0.37 nM and 0.26 nM for human 5-HT4A/4B/4D/4E, respectively. As for rat 5-HT4S/4L/4E, the EC50 is 0.59 nM, 0.65 nM and 0.62 nM, respectively. PF-04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer's disease.
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