Name:Staurosporine (AM-2282)
Synonyms:Antibiotic AM-2282, STS
CAS Number:62996-74-1
Formula:C28H26N4O3
M.w.:466.53
DMSO (mg/mL)Max Solubility:93
DMSO (mM)Max Solubility:199.34
Form:Free Base
SMILES:CNC1CC2OC(C)(C1OC)[N]3C4=C(C=CC=C4)C5=C6CNC(=O)C6=C7C8=CC=CC=C8[N]2C7=C35
ALogP:3.819
Target:ADC Cytotoxin,Antineoplastic and Immunosuppressive Antibiotics,CaMK,PKA,PKC,PKG,S6 Kinase
Pathway:TGF-beta/Smad
Information:Staurosporine (AM-2282, Antibiotic AM-2282, STS) is a potent PKC inhibitor for PKCα, PKCγ and PKCη with IC50 of 2 nM, 5 nM and 4 nM, less potent to PKCδ (20 nM), PKCε (73 nM) and little active to PKCζ (1086 nM) in cell-free assays. Also shows inhibitory activities on other kinases, such as PKA, PKG, S6K, CaMKII, etc. Phase 3.
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