Name:KU-55933 (ATM Kinase Inhibitor)
Synonyms:N/A
CAS Number:587871-26-9
Formula:C21H17NO3S2
M.w.:395.49
DMSO (mg/mL)Max Solubility:33
DMSO (mM)Max Solubility:83.44
Form:free base
SMILES:O=C1C=C(OC(=C1)C2=CC=CC3=C2SC4=CC=CC=C4S3)N5CCOCC5
ALogP:4.393
Target:ATM/ATR,Autophagy,ULK
Pathway:DNA Damage/DNA Repair
Information:KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor with IC50/Ki of 12.9 nM/2.2 nM in cell-free assays, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR. KU‑55933 (ATM Kinase Inhibitor) inhibits the activation of autophagy‑initiating kinase ULK1 and results in a significant decrease of autophagy.
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