Name:Buparlisib (BKM120)
Synonyms:NVP-BKM120
CAS Number:944396-07-0
Formula:C18H21F3N6O2
M.w.:410.39
DMSO (mg/mL)Max Solubility:82
DMSO (mM)Max Solubility:199.81
Form:free base
SMILES:NC1=CC(=C(C=N1)C2=NC(=NC(=C2)N3CCOCC3)N4CCOCC4)C(F)(F)F
ALogP:2.342
Target:Apoptosis related,PI3K
Pathway:PI3K/Akt/mTOR
Information:Buparlisib (BKM120, NVP-BKM120) is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM in cell-free assays, respectively. Reduced potency against VPS34, mTOR, DNAPK, with little activity to PI4Kβ. Buparlisib induces apoptosis. Phase 2.
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