Name:Dovitinib (TKI-258) Dilactic Acid
Synonyms:N/A
CAS Number:852433-84-2
Formula:C27H33FN6O7
M.w.:572.59
DMSO (mg/mL)Max Solubility:90
DMSO (mM)Max Solubility:157.18
Form:Dilactic Acid
SMILES:CC(O)C(O)=O.CC(O)C(O)=O.CN1CCN(CC1)C2=CC=C3N=C([NH]C3=C2)C4=C(N)C5=C(NC4=O)C=CC=C5F
ALogP:-2.038
Target:c-Kit,FGFR,FLT3,PDGFR,VEGFR
Pathway:Angiogenesis
Information:Dovitinib Dilactic acid (TKI258 Dilactic acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGFR1 and HER2. Phase 4.
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