Name:Tacrolimus (FK506)
Synonyms:FK506, FR900506, Fujimycin, Prograf
CAS Number:104987-11-3
Formula:C44H69NO12
M.w.:804.02
DMSO (mg/mL)Max Solubility:94
DMSO (mM)Max Solubility:116.91
Form:free base
SMILES:COC1CC(CCC1O)\C=C(C)\C2OC(=O)C3CCCCN3C(=O)C(=O)C4(O)OC(C(CC(C)C/C(=C/C(CC=C)C(=O)CC(O)C2C)C)OC)C(CC4C)OC
ALogP:4.832
Target:Autophagy,FKBP,phosphatase
Pathway:PI3K/Akt/mTOR
Information:Tacrolimus (FK506, FR900506, Fujimycin, Prograf) is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity in T cells by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. Tacrolimus also inhibits the phosphatase activity of calcineurin. Tacrolimus induces vascular endothelial autophagy.
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