Name:Cariprazine hydrochloride
Synonyms:RGH188 hydrochloride
CAS Number:1083076-69-0
Formula:C21H32Cl2N4O.HCl
M.w.:463.87
DMSO (mg/mL)Max Solubility:12
DMSO (mM)Max Solubility:25.87
Form:hydrochloride
SMILES:Cl.CN(C)C(=O)NC1CCC(CC1)CCN2CCN(CC2)C3=C(Cl)C(=CC=C3)Cl
ALogP:4.934
Target:Dopamine Receptor
Pathway:Neuronal Signaling
Information:Cariprazine hydrochloride(RGH188 hydrochloride) is a novel antipsychotic agent and is a highly selective partial agonist of dopamineD2 and D3 and 5HT1A receptors, with preferential binding to the D3 receptor. It exhibits high selectivity and affinity to dopamine D3 (Ki = 0.085 nM) and D2 (Ki = 0.49 nM) receptors and has moderate affinity for the 5-HT1A receptor (Ki = 2.6 nM).
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