Name:BX-795
Synonyms:N/A
CAS Number:702675-74-9
Formula:C23H26IN7O2S
M.w.:591.47
DMSO (mg/mL)Max Solubility:100
DMSO (mM)Max Solubility:169.07
Form:free base
SMILES:IC1=CN=C(NC2=CC(=CC=C2)NC(=O)N3CCCC3)N=C1NCCCNC(=O)C4=CC=CS4
ALogP:3.704
Target:Autophagy,IκB/IKK,PDPK1,TBK1
Pathway:PI3K/Akt/mTOR
Information:BX-795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, 140- and 1600-fold more selective for PDK1 than PKA and PKC in cell-free assays, respectively. Meanwhile, in comparison to GSK3β more than 100-fold selectivity observed for PDK1. BX-795 modulates autophagy via inhibiting ULK1. BX-795 also is a potent TBK1 inhibitor that blocks both TBK1 and IKKε with IC 50 values of 6 nM and 41 nM, respectively.
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