Name:Linagliptin (BI-1356)
Synonyms:GSK2118436
CAS Number:668270-12-0
Formula:C25H28N8O2
M.w.:472.54
DMSO (mg/mL)Max Solubility:17
DMSO (mM)Max Solubility:35.98
Form:free base
SMILES:CC#CC[N]1C(=NC2=C1C(=O)N(CC3=NC4=CC=CC=C4C(=N3)C)C(=O)N2C)N5CCCC(N)C5
ALogP:2.718
Target:Autophagy,Ferroptosis
Pathway:Proteases
Information:Linagliptin (BI-1356,GSK2118436) is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM and exhibits a 10,000-fold higher selectivity for DPP-4 than for other dipeptidyl peptidases such as DPP-2, DPP-8, and DPP-9. Linagliptin activates glomerular autophagy in a model of type 2 diabetes. DPP4 mediates ferroptosis in TP53-deficient CRC cells.
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