Name:Valproic Acid (NSC 93819) sodium salt
Synonyms:Sodium valproate,NSC 93819,2-Propylpentanoic Acid
CAS Number:1069-66-5
Formula:C8H15NaO2
M.w.:166.19
DMSO (mg/mL)Max Solubility:33
DMSO (mM)Max Solubility:198.57
Form:Sodium salt
SMILES:CCCC(CCC)C(=O)O[Na]
ALogP:1.275
Target:Autophagy,GABA Receptor,HDAC,Mitophagy,Notch,PGC-1α
Pathway:Neuronal Signaling
Information:Valproic Acid sodium salt (NSC 93819, Sodium valproate) is a HDAC inhibitor by selectively inducing proteasomal degradation of HDAC2, used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. Valproic acid induces Notch1 signaling in small cell lung cancer (SCLC) cells. Valproic acid is under investigation for treatment of HIV and various cancers. Valproic acid (VPA) induces autophagy and mitophagy by upregulation of BNIP3 and mitochondrial biogenesis by upregulating PGC-1α.
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