Name:Quetiapine
Synonyms:ICI204636
CAS Number:111974-69-7
Formula:C21H25N3O2S
M.w.:383.51
DMSO (mg/mL)Max Solubility:77
DMSO (mM)Max Solubility:200.78
Form:Free Base
SMILES:OCCOCCN1CCN(CC1)C2=NC3=CC=CC=C3SC4=C2C=CC=C4
ALogP:2.656
Target:5-HT Receptor,Dopamine Receptor
Pathway:Neuronal Signaling
Information:Quetiapine(ICI204636) is an atypical antipsychotic used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder.Quetiapine is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine have moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.23, 5.74, 7.54, 5.55.
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