Name:Baricitinib phosphate
Synonyms:INCB-028050 phosphate, LY-3009104 phosphate
CAS Number:1187595-84-1
Formula:C16H20N7O6PS
M.w.:469.41
DMSO (mg/mL)Max Solubility:94
DMSO (mM)Max Solubility:200.25
Form:phosphate
SMILES:CC[S](=O)(=O)N1CC(CC#N)(C1)[N]2C=C(C=N2)C3=NC=NC4=C3C=C[NH]4.O[P](O)(O)=O
ALogP:-0.108
Target:COVID-19,JAK
Pathway:JAK/STAT
Information:Baricitinib phosphate (INCB-028050, LY-3009104) is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2. Baricitinib is found to reduce or interrupt the passage of the virus into target cells and is used in the treatment research for COVID-19.
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