Name:Vadimezan (ASA404)
Synonyms:NSC 640488, DMXAA
CAS Number:117570-53-3
Formula:C17H14O4
M.w.:282.29
DMSO (mg/mL)Max Solubility:7
DMSO (mM)Max Solubility:24.8
Form:free base
SMILES:CC1=C(C)C2=C(C=C1)C(=O)C3=C(O2)C(=CC=C3)CC(O)=O
ALogP:3.601
Target:Antiviral,IFN,STING,TNF-alpha,VDA
Pathway:Angiogenesis
Information:Vadimezan (ASA404, NSC 640488, DMXAA) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively. DMXAA (Vadimezan) is also a STING agonist with potential antineoplastic activity. DMXAA (Vadimezan) potently induces IFN-β but relatively low TNF-α expression in vitro. DMXAA (Vadimezan) has antiviral activity. Phase 3.
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