生物活性：Filgotinib-d4 is the deuterium labeled Filgotinib. Filgotinib (GLPG0634) is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively.
体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘代因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Filgotinib-d4 相关抗体:
Phospho-JAK2 (Tyr1007/1008) Antibody
JAK1 Antibody (YA722)
JAK1 Antibody
JAK2 Antibody (YA721)
Phospho-JAK2 (Tyr1007+Tyr1008) Antibody
JAK2 Antibody (YA330)
Phospho-JNK (Thr183) Antibody
JAK3 Antibody (YA2466)
分子量：429.53
Formula：C21H19D4N5O3S
CAS 号：2041095-50-3
非标记 CAS：1206161-97-8
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (535 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
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[2]. Van Rompaey L, et al. Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases. J Immunol. 2013, 191(7), 3568-3577.
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[3]. Menet CJ, et al. Triazolopyridines as Selective JAK1 Inhibitors: From Hit Identification to GLPG0634. J Med Chem. 2014 Nov 17.
 [Content Brief]