生物活性：Sulfadoxine-d3 is a deuterium labeled Sulfadoxine (HY-B0439). Sulfadoxine is a sulfonamide that is used, usually in combination with Pyrimethamine.html" class="link-product" target="_blank">Pyrimethamine (HY-18062), for multidrug-resistant Plasmodium falciparum and P. vivax inhibition. Unlike PYR, Sulfadoxine has no impact on HIV replication or MT-2 cell cycle progression. But also Sulfadoxine exhibits suppression on respiratory, and urinary tract infections[1][2][3][4].
IC50 & Target：Plasmodium
体外研究(In Vitro)：磺胺多辛 (0-100 μM;7 d) 对 MT-2 细胞中 HIV-1 的复制无影响[4].
磺胺多辛 (100 μM;48 h) 对 MT-2 细胞 S 期积累的诱导无影响[4].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)
磺胺多辛 (0.1, 0.3, 10 mg/kg/d; 口服; 每日1次, 连用 3天) 与阿奇霉素 (30 mg/kg/d; 口服; 每日1次, 连用 3天)，能够抑制小鼠疟疾模型中的血期寄生虫或约氏疟原虫子孢子[5].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量：313.35
Formula：C12H11D3N4O4S
CAS 号：1262770-70-6
非标记 CAS：2447-57-6
性状：固体
颜色：White to off-white
中文名称：磺胺多辛-d3
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Powder：-20°C：3 years，4°C：2 years
In solvent：-80°C：6 months，-20°C：1 month