生物活性：Sunitinib-d10 is a deuterium labeled Sunitinib. Sunitinib is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively[1]. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation[2].
IC50 & Target[1]：VEGFR2
80 nM (IC50)
PDGFRβ
2 nM (IC50)
分子量：408.54
Formula：C22H17D10FN4O2
CAS 号：1126721-82-1
非标记 CAS：557795-19-4
性状：固体
颜色：White to yellow
中文名称：舒尼替尼 d10
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Powder：-20°C：3 years，4°C：2 years
In solvent：-80°C：6 months，-20°C：1 month