生物活性：Lumacaftor-d4 is the deuterium labeled Lumacaftor (HY-13262)[1].
体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)
Oral dosing of 1 mg/kg Lumacaftor in male Sprague-Dawley rats results in a Cmax of 2.4±1.3 μM with a t1/2 of 7.7±0.4 h (mean±SD; n=3), indicating that that Lumacaftor is orally bioavailable and able to reach plasma levels that significantly exceeded EC50s for F508del-CFTR correction[2].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量：456.43
Formula：C24H14D4F2N2O5
CAS 号：2733561-44-7
非标记 CAS：936727-05-8
性状：固体
颜色：White to off-white
中文名称：鲁玛卡托-d4
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Powder：-20°C：3 years，4°C：2 years
In solvent：-80°C：6 months，-20°C：1 month