生物活性：Raloxifene-d10-1 is the deuterium labeled Raloxifene[1]. Raloxifene (Keoxifene) is a benzothiophene-derived selective estrogen receptor modulator (SERM). Raloxifene has estrogen-agonistic effects on bone and lipids and estrogen-antagonistic effects on the breast and uterus. Raloxifene is used for breast cancer and osteoporosis research[2].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Raloxifene-d10-1 相关抗体:
Estrogen Receptor alpha Antibody (YA768)
Estrogen Receptor alpha Antibody
GPR30 Antibody
PBR Antibody (YA1785)
REA Antibody (YA1848)
Estrogen Related Receptor gamma Antibody (YA2009)
ERR alpha Antibody (YA2283)
Estrogen Receptor beta Antibody (YA1892)
14-3-3 Antibody (YA1949)
Estrogen Inducible Protein pS2 Antibody (YA2377)
MVK Antibody (YA3093)
分子量：483.64
Formula：C28H17D10NO4S
CAS 号：2512224-37-0
非标记 CAS：84449-90-1
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (533 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
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[2]. Khovidhunkit W, et al. Clinical effects of raloxifene hydrochloride in women. Ann Intern Med. 1999;130(5):431-439.
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[3]. Xu H, et al. Effect of caffeine on ovariectomy-induced osteoporosis in rats. Biomed Pharmacother. 2019112:108650.
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