生物活性：4-Phenylbutyric acid-d5 is the deuterium labeled 4-Phenylbutyric acid[1]. 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research[2][3][4].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
4-Phenylbutyric acid-d5 相关抗体:
S100A10 Antibody (YA675)
HDAC1 Antibody
HDAC6 Antibody
HDAC4 Antibody (YA741)
SATB2 Antibody
HDAC10 Antibody
HDAC2 Antibody
HDAC3 Antibody
HDAC4 Antibody
HDAC2 Antibody (YA742)
SNAI1 Antibody
HDAC11 Antibody (YA2884)
HDAC9 Antibody (YA2967)
HDAC8 Antibody (YA2994)
HDAC6 Antibody (YA740)
SATB1 Antibody (YA1154)
HDAC7 Antibody (YA3146)
分子量：169.23
Formula：C10H7D5O2
CAS 号：64138-52-9
非标记 CAS：1821-12-1
中文名称：4-苯基丁酸-d5
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (528 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
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[2]. Chang TH, et al. Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung. Clin Cancer Res. 2002 Apr;8(4):1206-12.
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[3]. Frouco G, et, al. Sodium phenylbutyrate abrogates African swine fever virus replication by disrupting the virus-induced hypoacetylation status of histone H3K9/K14. Virus Res. 2017 Oct 15;242:24-29.
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[4]. Park HJ, et al. 4-Phenylbutyric acid protects against lipopolysaccharide-induced bone loss by modulating autophagy in osteoclasts. Biochem Pharmacol. 2018 May;151:9-17.
 [Content Brief]