生物活性：Niclosamide-13C6 (monohydrate) is the 13C labeled Niclosamide monohydrate[1]. Niclosamide (BAY2353) monohydrate is an orally active antihelminthic agent used in parasitic infection research[2]. Niclosamide monohydrate is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells[5]. Niclosamide monohydrate has biological activities against cancer, and inhibits DNA replication in Vero E6 cells[3][4][6].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Niclosamide-13C6 monohydrate 相关抗体:
FOXP3 Antibody (YA858)
Phospho-STAT3 (Tyr705) Antibody (YA146)
STAT3 Antibody (YA056)
Phospho-STAT1 (Ser727) Antibody (YA148)
Phospho-STAT1 (Tyr701) Antibody
Phospho-STAT3 (Tyr705) Antibody
FOXP3 Antibody
Phospho-STAT3 (Ser727) Antibody
STAT1 Antibody (YA059)
STAT1 Antibody (YA667)
STAT1 alpha Antibody
STAT2 Antibody (YA057)
STAT5a Antibody
STAT5b Antibody
STAT6 Antibody
Phospho-STAT5 (Tyr694) Antibody (YA145)
FOXP3 Antibody (YA759)
Phospho-STAT1 (Ser727) Antibody (YA149)
STAT3 Antibody (YA666)
STAT4 Antibody
STAT5 Antibody
Phospho-STAT5(Tyr694) Antibody (YA1513)
T-bet / Tbx21 Antibody (YA1217)
MVP Antibody (YA1417)
T Box Protein 21 Antibody (YA1502)
分子量：351.09
Formula：C713C6H10Cl2N2O5
CAS 号：1325559-12-3
非标记 CAS：50-65-7
中文名称：氯硝柳胺一水合物-13C6
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (528 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
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[2]. P Andrews, et al. The biology and toxicology of molluscicides, Bayluscide. Pharmacol Ther. 1982;19(2):245-95.
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[3]. Wei Chen, et al. Niclosamide: Beyond an antihelminthic drug. Cell Signal. 2018 Jan41:89-96.
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[4]. Kei Satoh, et al. Identification of Niclosamide as a Novel Anticancer Agent for Adrenocortical Carcinoma. Clin Cancer Res. 2016 Jul 1522(14):3458-66.
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[5]. Xiaomei Ren, et al. Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway. ACS Med Chem Lett. 2010 Sep 71(9):454-9.
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[6]. Chang-Jer Wu, et al. Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide. Antimicrob Agents Chemother. 2004 Jul48(7):2693-6.
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