生物活性：Bazedoxifene-d4 (acetate) is the deuterium labeled Bazedoxifene[1]. Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene can be used for the research of osteoporosis. Bazedoxifene also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer[2][3].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Bazedoxifene-d4 acetate 相关抗体:
Estrogen Receptor alpha Antibody (YA768)
Estrogen Receptor alpha Antibody
GPR30 Antibody
PBR Antibody (YA1785)
REA Antibody (YA1848)
Estrogen Related Receptor gamma Antibody (YA2009)
ERR alpha Antibody (YA2283)
Estrogen Receptor beta Antibody (YA1892)
14-3-3 Antibody (YA1949)
Estrogen Inducible Protein pS2 Antibody (YA2377)
MVK Antibody (YA3093)
分子量：534.68
Formula：C32H34D4N2O5
CAS 号：1795027-71-2
非标记 CAS：198481-32-2
中文名称：巴多昔芬-d4
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (535 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
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[2]. Barry S Komm, et al. Bazedoxifene acetate: a selective estrogen receptor modulator with improved selectivity. Endocrinology. 2005 Sep;146(9):3999-4008.
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[3]. Xiaojuan Wu, et al. Bazedoxifene as a Novel GP130 Inhibitor for Pancreatic Cancer Therapy. Mol Cancer Ther. 2016 Nov 15(11): 2609–2619.
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