生物活性：Oxaprozin-d5 is deuterium labeled Oxaprozin. Oxaprozin is an inhibitor of both COX-1 and COX-2 with IC50s of 2.2 μM and 36 μM for human platelet COX-1 and IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB.
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Oxaprozin-d5 相关抗体:
NF-KB p65 Antibody
Phospho-NF-KB p65 (Ser536) Antibody
Phospho-NF-κB p65 (Ser529) Antibody
COX2 Antibody
NF-KB p65 Antibody (YA267)
COX IV Antibody
COX2/Cyclooxygenase 2 Antibody
NF-KB p105/p50 Antibody
RelB Antibody
Ret Antibody
Retinoic Acid Receptor alpha Antibody
SOD2 Antibody (YA071)
SOX1 Antibody
TRAF2 Antibody
Annexin A1 Antibody (YA832)
DDX3 Antibody (YA784)
NF-KB p100 Antibody
NF-KB p105 Antibody (YA700)
Nrf1 Antibody
Phospho-NF-KB p65 (Thr254) Antibody
SOD2 Antibody (YA670)
TRAF6 Antibody
COX IV Antibody (YA867)
Phospho-NFKB1(Ser337) Antibody
Nrf2 Antibody(YA895)
DDIT3 Antibody
Phospho-NF-κB p65 (Ser536) Antibody
Cyclooxygenase 1 Antibody (YA2537)
Cyclooxygenase 2 Antibody (YA2541)
c-Rel Antibody
分子量：298.35
Formula：C18H10D5NO3
CAS 号：2933758-40-6
非标记 CAS：21256-18-8
中文名称：奥沙普秦-d5；恶丙嗪-d5
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (532 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
 [Content Brief]
[2]. Ottonello L, et al. Delayed apoptosis of human monocytes exposed to immune complexes is reversed byoxaprozin: role of the Akt/IkappaB kinase/nuclear factor kappaB pathway. Br J Pharmacol. 2009 May;157(2):294-306.
 [Content Brief]
[3]. Montecucco F, et al. Oxaprozin-induced apoptosis on CD40 ligand-treated human primary monocytes is associated with the modulation of defined intracellular pathways. J Biomed Biotechnol. 2009;2009:478785.
 [Content Brief]