生物活性：Hydrochlorothiazid-13C,d2 is the 13C- and deuterium labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect[1][2][3].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[71].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Hydrochlorothiazid-13C,d2 相关抗体:
Smad3 Antibody
TGF beta 1 Antibody
Smad1 Antibody
Smad2 Antibody
Smad4 Antibody
Smad5 Antibody
Phospho-Smad3 (Ser423/Ser425) Antibody
ATP1A1 Antibody
CD105 Antibody (YA547)
Noggin Antibody (YA698)
Phospho-Smad1 (Ser463/Ser465) Antibody
Phospho-Smad2 (Ser250) Antibody
Phospho-Smad3 (Ser423/425) Antibody
Smad2/3 Antibody
Inhibin beta A Antibody (YA2780)
Phospho-Smad5 (Ser463/465) Antibody (YA2838)
LGI1 Antibody (YA2885)
Inhibin alpha Antibody (YA1232)
Inhibin beta B Antibody (YA1677)
Cardiac Troponin C Antibody (YA2125)
Phospho-NDRG1 (Ser330) Antibody (YA2618)
Cardiac Troponin T Antibody (YA2719)
SAP97 Antibody (YA2731)
Kir2.1 Antibody (YA2871)
SARA Antibody (YA3226)
分子量：300.74
Formula：C613CH6D2ClN3O4S2
CAS 号：1190006-03-1
非标记 CAS：58-93-5
性状：固体
颜色：White to off-white
中文名称：氢氯噻嗪-13C,d2
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Powder：-20°C：3 years
In solvent：-80°C：6 months，-20°C：1 month
纯度 & 产品资料
纯度： 98.64%
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.
 [Content Brief]
[2]. Duarte, J.D. and R.M. Cooper-DeHoff, Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics. Expert Rev Cardiovasc Ther, 2010. 8(6): p. 793-802.
 [Content Brief]
[3]. Jinghong Luo, et al. Hydrochlorothiazide modulates ischemic heart failure-induced cardiac remodeling via inhibiting angiotensin II type 1 receptor pathway in rats. Cardiovasc Ther. 2017 Apr;35(2).
 [Content Brief]
[4]. Magdy M Abdelquader, et al. Inhibition of Co-Crystallization of Olmesartan Medoxomil and Hydrochlorothiazide for Enhanced Dissolution Rate in Their Fixed Dose Combination. AAPS PharmSciTech. 2018 Dec 17;20(1):3.
 [Content Brief]