生物活性：Roxadustat-d5 is deuterium labeled Roxadustat. Roxadustat is an oral hypoxia-inducible factor prolyl-hydroxylase inhibitor (HIF-PHI) that promotes erythropoiesis through increasing endogenous erythropoietin, improving iron regulation, and reducing hepcidin[1].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Roxadustat-d5 相关抗体:
Ferritin Heavy Chain Antibody
HIF1 alpha Antibody
HIF1 beta Antibody
AMID/FSP1 Antibody
Peroxiredoxin 1 Antibody (YA692)
PRDX3 Antibody (YA909)
HIF 2 alpha Antibody
CA9 Antibody (YA1368)
HIF2 alpha Antibody (YA1445)
ORP150 Antibody (YA1478)
PHD3 Antibody (YA1612)
CITED2 Antibody (YA2596)
Ferritin Light Chain Antibody (YA971)
Ferritin Light Chain Antibody (YA972)
ORP1 Antibody (YA1477)
HIF1AN Antibody (YA1907)
OS9 Antibody (YA1939)
PHD2 Antibody (YA2431)
HIF Prolyl Hydroxylases Antibody (YA2975)
HLF Antibody (YA2990)
PHD1 Antibody (YA3325)
分子量：357.37
Formula：C19H11D5N2O5
CAS 号：2043026-13-5
非标记 CAS：808118-40-3
性状：固体
颜色：White to off-white
中文名称：罗沙司他-d5
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：-20°C, sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
纯度 & 产品资料
纯度： ≥98.0%
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
 [Content Brief]
[2]. Provenzano R, et al. Roxadustat (FG-4592) Versus Epoetin Alfa for Anemia in Patients Receiving MaintenanceHemodialysis: A Phase 2, Randomized, 6- to 19-Week, Open-Label, Active-Comparator, Dose-Ranging, Safety and Exploratory Efficacy Study. Am J Kidney Dis. 2016 Jun;67(6):912-24.
 [Content Brief]
[3]. Wu K, et al. Stabilization of HIF-1α by FG-4592 promotes functional recovery and neural protection in experimental spinal cord injury. Brain Res. 2016 Feb 1;1632:19-26.
 [Content Brief]