生物活性：Ponatinib-d8 is a deuterium labeled Ponatinib. Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.
IC50 & Target[1]：c-Kit
12.5 nM (IC50)
VEGFR2
1.5 nM (IC50)
FGFR1
2.2 nM (IC50)
PDGFRα
1.1 nM (IC50)
分子量：540.61
Formula：C29H19D8F3N6O
CAS 号：1562993-37-6
非标记 CAS：943319-70-8
性状：固体
颜色：White to light yellow
中文名称：帕纳替尼 d8
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Powder：-20°C：3 years，4°C：2 years
In solvent：-80°C：6 months，-20°C：1 month