生物活性：Riluzole-13C,15N2 is the 13C and 15N labeled Riluzole[1]. Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM[2][3].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Riluzole-13C,15N2 相关抗体:
xCT Antibody (YA006)
GABARAP Antibody
xCT Antibody (YA652)
Alpha-ENaC Antibody
IP3 Receptor Antibody (YA1596)
GABA B Receptor 2 Antibody (YA1733)
GABA B Receptor 1 Antibody (YA2418)
CRMP2 Antibody (YA3370)
GAD65 Antibody (YA758)
GABA A Receptor alpha 1 Antibody (YA1315)
SLC12A1 Antibody (YA1403)
GABA A Receptor beta 2 Antibody (YA1758)
GABA Transporter 1 Antibody (YA1795)
GAD67 Antibody (YA1807)
CRMP1 Antibody (YA1941)
ABAT Antibody (YA1964)
GABA A Receptor alpha 5 Antibody (YA2249)
GABA A Receptor beta 1 Antibody (YA2261)
CRMP5 Antibody (YA2497)
CRMP3 Antibody (YA2563)
BGAT Antibody (YA2741)
CRMP4 Antibody (YA2777)
GABARAPL2 Antibody (YA2882)
分子量：237.18
Formula：C713CH5F315N2OS
CAS 号：1215552-03-6
非标记 CAS：1744-22-5
性状：固体
颜色：White to off-white
中文名称：利鲁唑-13C,15N2
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：4°C, protect from light
*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
纯度 & 产品资料
纯度： 99.90%
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
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[2]. He Y, et al. Neuroprotective agent riluzole potentiates postsynaptic GABA(A) receptor function. Neuropharmacology. 2002 Feb;42(2):199-209.
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[3]. Thompson JM, et al. Small-conductance calcium-activated potassium (SK) channels in the amygdala mediate pain-inhibiting effects of clinically available riluzole in a rat model of arthritis pain. Mol Pain. 2015 Aug 2811:51.
 [Content Brief]