生物活性：Artemisinin-d3 is the deuterium labeled Artemisinin. Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants[1]. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects[2].
IC50 & Target：Plasmodium
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Artemisinin-d3 相关抗体:
Phospho-AKT1 (Ser473) Antibody
AKT1/2/3 Antibody (YA633)
Ferritin Heavy Chain Antibody
Phospho-AKT (Thr308) Antibody
Phospho-AKT1(Ser473) Antibody
AKT1 Antibody (YA834)
AKT1 Antibody (YA634)
Cyclophilin A Antibody
AKT1/AKT2/AKT3 Antibody (YA635)
Cyclophilin B Antibody (YA787)
AMID/FSP1 Antibody
Peroxiredoxin 1 Antibody (YA692)
PRDX3 Antibody (YA909)
TRIB3 Antibody (YA2174)
Ferritin Light Chain Antibody (YA971)
Ferritin Light Chain Antibody (YA972)
PDPK1 Antibody (YA1569)
AS160 Antibody (YA2170)
MPP1 Antibody (YA3077)
分子量：285.35
Formula：C15H19D3O5
CAS 号：176652-07-6
非标记 CAS：63968-64-9
中文名称：青蒿素 d3
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (543 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. ;Lin SP, et al. Artemisinin Prevents Glutamate-Induced Neuronal Cell Death Via Akt Pathway Activation. Front Cell Neurosci. 2018 Apr 20;12:108.;Zeng Z, et al. Artemisinin protects PC12 cells against β-amyloid-induced apoptosis through activation of the ERK1/2 signaling pathway. Redox Biol. 2017 Apr 4;12:625-633.
 [Content Brief]
[2]. Shao-Peng Lin, et al. Artemisinin Prevents Glutamate-Induced Neuronal Cell Death Via Akt Pathway Activation. Front Cell Neurosci. 2018 Apr 20;12:108.;Zeng Z,
 [Content Brief]
[3]. Zhiwen Zeng, et al. Artemisinin protects PC12 cells against β-amyloid-induced apoptosis through activation of the ERK1/2 signaling pathway. Redox Biol. 2017 Apr 4;12:625-633.
 [Content Brief]
[4]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
 [Content Brief]