生物活性：O-Desmethyl gefitinib-d8 is a deuterium labeled O-Desmethyl gefitinib. O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays[1][2].
IC50 & Target：IC50: 36 nM (EGFR)[2]
分子量：440.93
Formula：C21H14D8ClFN4O3
非标记 CAS：847949-49-9
性状：固体
颜色：White to off-white
中文名称：O-去甲基吉非替尼杂质8-d8
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Powder：-20°C：3 years，4°C：2 years
In solvent：-80°C：6 months，-20°C：1 month