生物活性：Furosemide-d5 is the deuterium labeled Furosemide. Furosemide is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2[1]. Furosemide is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema[2].
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Furosemide-d5 相关抗体:
GABARAP Antibody
IP3 Receptor Antibody (YA1596)
GABA B Receptor 2 Antibody (YA1733)
GABA B Receptor 1 Antibody (YA2418)
GAD65 Antibody (YA758)
GABA A Receptor alpha 1 Antibody (YA1315)
GABA A Receptor beta 2 Antibody (YA1758)
GABA Transporter 1 Antibody (YA1795)
GAD67 Antibody (YA1807)
ABAT Antibody (YA1964)
GABA A Receptor alpha 5 Antibody (YA2249)
GABA A Receptor beta 1 Antibody (YA2261)
BGAT Antibody (YA2741)
GABARAPL2 Antibody (YA2882)
分子量：335.77
Formula：C12H6D5ClN2O5S
CAS 号：1189482-35-6
非标记 CAS：54-31-9
性状：固体
颜色：White to off-white
中文名称：呋塞米 d5
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Powder：-20°C：3 years，4°C：2 years
In solvent：-80°C：6 months，-20°C：1 month