生物活性：Cyclosporin A-13C2,d4 (Cyclosporine A-13C2,d4; Ciclosporin A-13C2,d4) is a 13C labeled Cyclosporin A (HY-B0579)[1]. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM[2]. Cyclosporin A also inhibits CD11a/CD18 adhesion[3].
体外研究(In Vitro)：氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量：1208.62
Formula：C6013C2H107D4N11O12
非标记 CAS：59865-13-3
性状：固体
颜色：White to off-white
中文名称：环孢霉素A-13C2,d4；环孢素A-13C2,d4；环孢多肽A-13C2,d4；环孢灵-13C2,d4；赛斯平-13C2,d4；环孢素-13C2,d4
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：4°C, sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
纯度 & 产品资料
纯度： 95.21%
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-246.
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