生物活性：Omecamtiv mecarbil-d8 is the deuterium labeled Omecamtiv mecarbil. Omecamtiv mecarbil (CK-1827452) is a selective cardiac myosin activator.
体外研究(In Vitro)：Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
德尔塔生物 has not independently confirmed the accuracy of these methods. They are for reference only.
Omecamtiv mecarbil-d8 相关抗体:
Moesin Antibody
Myosin heavy chain Antibody
Myosin Light Chain 2 Antibody
Myosin light chain kinase Antibody
Calponin 1 Antibody
MYO7A Antibody (YA1665)
MYL9 Antibody (YA2093)
Tropomyosin alpha 1 Chain Antibody (YA2183)
Phospho-Moesin (Thr558) Antibody (YA2614)
MYL2 Antibody (YA2709)
MYH9 Antibody (YA3113)
MYH10 Antibody (YA3114)
MYLK Antibody (YA3133)
MYH6 Antibody (YA3200)
MYH11 Antibody (YA1620)
Troponin I Antibody (YA1832)
Tropomodulin 2 Antibody (YA2771)
MYH7B Antibody (YA2857)
MYO19 Antibody (YA3282)
MYO1B Antibody (YA3284)
分子量：409.48
Formula：C20H16D8FN5O3
非标记 CAS：873697-71-3
运输条件：Room temperature in continental US; may vary elsewhere.
储存方式：Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (524 KB)
产品使用指南 (1538 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
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[2]. Morgan BP, et al. Discovery of omecamtiv mecarbil the first, selective, small molecule activator of cardiac Myosin. ACS Med Chem Lett. 2010 Aug 20;1(9):472-7.
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[3]. Mamidi R, et al. Molecular effects of the myosin activator omecamtiv mecarbil on contractile properties of skinned myocardium lacking cardiac myosin binding protein-C. J Mol Cell Cardiol. 2015 Aug;85:262-72.
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[4]. Swenson AM, et al. Omecamtiv Mecarbil Enhances the Duty Ratio of Human β-Cardiac Myosin Resulting in Increased Calcium Sensitivity and Slowed Force Development in Cardiac Muscle. J Biol Chem. 2017 Mar 3;292(9):3768-3778.
 [Content Brief]