Name:Dacarbazine (NSC-45388)
Synonyms:DTIC-Dome, Imidazole Carboxamide,NSC-45388
CAS Number:4342-03-4
Formula:C6H10N6O
M.w.:182.18
DMSO (mg/mL)Max Solubility:12
DMSO (mM)Max Solubility:65.87
Form:free base
SMILES:CN(C)N=NC1=C(N=C[NH]1)C(N)=O
ALogP:-0.344
Target:Antineoplastic and Immunosuppressive Antibiotics,DNA/RNA Synthesis
Pathway:DNA Damage/DNA Repair
Information:Dacarbazine (NSC-45388, DTIC-Dome, Imidazole Carboxamide) is a triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis; used in the treatment of various cancers.
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