Name:Letrozole (CGS 20267)
Synonyms:CGS 20267,Femara, Piroxicam
CAS Number:112809-51-5
Formula:C17H11N5
M.w.:285.3
DMSO (mg/mL)Max Solubility:57
DMSO (mM)Max Solubility:199.79
Form:free base
SMILES:N#CC1=CC=C(C=C1)C([N]2C=NC=N2)C3=CC=C(C=C3)C#N
ALogP:2.749
Target:Aromatase,Autophagy
Pathway:Endocrinology & Hormones
Information:Letrozole (CGS 20267,Femara, Piroxicam) is a third generation inhibitor of aromatase with IC50 of 0.07-20 nM in cell-free assays.It has no effect on the plasma levels of 17α-OH progesterone, thyroid-stimulating hormone (TSH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), or androstenedione and does not affect normal urine electrolyte excretion or thyroid function in clinical studies. Letrozole induces autophagy.
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