Name:Acalabrutinib (ACP-196)
Synonyms:N/A
CAS Number:1420477-60-6
Formula:C26H23N7O2
M.w.:465.51
DMSO (mg/mL)Max Solubility:93
DMSO (mM)Max Solubility:199.78
Form:free base
SMILES:CC#CC(=O)N1CCCC1C2=NC(=C3[N]2C=CN=C3N)C4=CC=C(C=C4)C(=O)NC5=NC=CC=C5
ALogP:2.699
Target:BTK
Pathway:Angiogenesis
Information:Acalabrutinib (ACP-196) is a selective second-generation Bruton's tyrosine kinase (BTK) inhibitor with an IC50 of 3 nM, which prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. ACP-196 has improved target specificity over ibrutinib with 323-, 94-, 19- and 9-fold selectivity over the other TEC kinase family members (ITK, TXK, BMX, and TEC, respectively) and no activity against EGFR.
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