Name:Mivebresib (ABBV-075)
Synonyms:N/A
CAS Number:1445993-26-9
Formula:C22H19F2N3O4S
M.w.:459.47
DMSO (mg/mL)Max Solubility:91
DMSO (mM)Max Solubility:198.05
Form:free base
SMILES:CC[S](=O)(=O)NC1=CC(=C(OC2=C(F)C=C(F)C=C2)C=C1)C3=CN(C)C(=O)C4=C3C=C[NH]4
ALogP:3.027
Target:Apoptosis related,Epigenetic Reader Domain
Pathway:Epigenetics
Information:Mivebresib (ABBV-075) is a novel BET family bromodomain inhibitor. It binds bromodomains of BRD2/4/T with similar affinities (Ki of 1-2.2 nM) and highly selective for 18 bromodomain proteins tested (Kd > 1 μM; more than 600-fold selectivity vs. BRD4), but exhibits roughly 10-fold weaker potency towards BRD3 (Ki of 12.2 nM) and has moderate activity towards CREBBP (Kd = 87 μM; 54-fold selectivity vs. BRD4). Mivebresib(ABBV-075) efficiently triggers apoptosis in various tumor cell.
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