Name:Sorafenib (BAY 43-9006) tosylate
Synonyms:BAY 43-9006 tosylate,NSC-724772 tosylate
CAS Number:475207-59-1
Formula:C21H16ClF3N4O3.C7H8O3S
M.w.:637.03
DMSO (mg/mL)Max Solubility:127
DMSO (mM)Max Solubility:199.36
Form:Tosylate
SMILES:CNC(=O)C1=CC(=CC=N1)OC2=CC=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C=C2.CC4=CC=C(C=C4)[S](O)(=O)=O
ALogP:5.824
Target:Apoptosis related,Autophagy,c-Kit,Ferroptosis,FGFR,FLT3,PDGFR,Raf,VEGFR
Pathway:MAPK
Information:Sorafenib tosylate (BAY 43-9006 tosylate,NSC-724772 tosylate) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib Tosylate inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib Tosylate induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.
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