Name:Rubitecan
Synonyms:9-NC, 9-Nitro-camptothecin, Partaject Orathecin, Partaject rubitecan, RFS 2000
CAS Number:91421-42-0
Formula:C20H15N3O6
M.w.:393.35
DMSO (mg/mL)Max Solubility:58
DMSO (mM)Max Solubility:147.45
Form:Free Base
SMILES:CCC1(O)C(=O)OCC2=C1C=C3N(CC4=C3N=C5C=CC=C(C5=C4)[N+]([O-])=O)C2=O
ALogP:1.64
Target:Topoisomerase
Pathway:DNA Damage/DNA Repair
Information:Rubitecan (9-NC, 9-Nitro-camptothecin, Partaject Orathecin, Partaject rubitecan, RFS 2000) is a topoisomerase I inhibitor extracted from the bark and leaves of the Camptotheca acuminata tree, which is native to China. Rubitecan is an oral camptothecin with antitumour activity.
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