Name:Anle138b
Synonyms:N/A
CAS Number:882697-00-9
Formula:C16H11BrN2O2
M.w.:343.17
DMSO (mg/mL)Max Solubility:69
DMSO (mM)Max Solubility:201.07
Form:Free Base
SMILES:BrC1=CC(=CC=C1)C2=CC(=N[NH]2)C3=CC=C4OCOC4=C3
ALogP:4.547
Target:Others
Pathway:Neuronal Signaling
Information:Anle138b is a novel oligomer modulator and an aggregation inhibitor, blocking the formation of pathological aggregates of prion protein (PrP(Sc)) and of α-synuclein (α-syn) with good oral bioavailability, blood-brain-barrier penetration and no detectable toxicity. Anle138b shows a new approach for disease-modifying therapy in neurodegenerative diseases such as prion and Parkinson's disease.
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