Name:3'-Fluoro-3'-deoxythymidine (Alovudine)
Synonyms:CL 184824, FddThd, FLT, MIV-310
CAS Number:25526-93-6
Formula:C10H13FN2O4
M.w.:244.22
DMSO (mg/mL)Max Solubility:49
DMSO (mM)Max Solubility:200.64
Form:Free Base
SMILES:CC1=CN(C2CC(F)C(CO)O2)C(=O)NC1=O
ALogP:-0.298
Target:DNA/RNA Synthesis,HIV,Reverse Transcriptase
Pathway:Microbiology
Information:3'-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. 3'-Fluoro-3'-deoxythymidine (Alovudine) is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer.
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