Name:Solasodine
Synonyms:Purapuridine, Solancarpidine, Solasodin, Salasodine, Salasdine
CAS Number:126-17-0
Formula:C27H43NO2
M.w.:413.64
DMSO (mg/mL)Max Solubility:2
DMSO (mM)Max Solubility:4.84
Form:free base
SMILES:CC1CCC2(NC1)OC3CC4C5CC=C6CC(O)CCC6(C)C5CCC4(C)C3C2C
ALogP:4.367
Target:Akt,MicroRNA,MMP,PI3K
Pathway:Proteases
Information:Solasodine (Purapuridine, Solancarpidine, Solasodin, Salasodine, Salasdine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine reduces the mRNA level of matrix metalloproteinase-2 (MMP-2), MMP-9 and extracellular inducer of matrix metalloproteinase (EMMPRIN), but increases the expression of reversion-inducing cysteine-rich protein with kazal motifs (RECK). Solasodine downregulates oncogenic microRNA-21 (miR-21), which has been known to target RECK. Solasodine also reduces PI3K/Akt signaling pathways and downregulates expression of miR-21.
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