Name:(+)-α-Lipoic acid
Synonyms:(R)-(+)-α-Lipoic acid, α-Lipoic acid, Alpha-Lipoic acid
CAS Number:1200-22-2
Formula:C8H14O2S2
M.w.:206.33
DMSO (mg/mL)Max Solubility:41
DMSO (mM)Max Solubility:198.71
Form:free base
SMILES:OC(=O)CCCCC1CCSS1
ALogP:2.258
Target:LTR,NF-κB
Pathway:NF-κB
Information:(+)-α-Lipoic acid ((R)-(+)-α-Lipoic acid, α-Lipoic acid, Alpha-Lipoic acid), a physiological form of thioctic acid, is a strong antioxidant that relieves diabetic neuropathic symptoms. It shows superior antioxidative effects to its racemate. R(+)-α-lipoic acid is an essential cofactor of mitochondrial enzyme complexes. R(+)-α-lipoic acid inhibits NF-κB-dependent HIV-1 LTR activation.
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