Name:Imidafenacin
Synonyms:KRP-197, ONO-8025
CAS Number:170105-16-5
Formula:C20H21N3O
M.w.:319.4
DMSO (mg/mL)Max Solubility:63
DMSO (mM)Max Solubility:197.24
Form:free base
SMILES:CC1=NC=C[N]1CCC(C(N)=O)(C2=CC=CC=C2)C3=CC=CC=C3
ALogP:2.55
Target:AChR
Pathway:GPCR & G Protein
Information:Imidafenacin (KRP-197, ONO-8025) is a urinary antispasmodic of the anticholinergic class. It is a novel antimuscarinic agent with safety and efficacy, has been clinically used for the treatment of overactive bladder. Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors(IC50=4.13 nM). IC50 value: 0.3 nM(M3).
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