Name:Isuzinaxib (APX-115 free base)
Synonyms:Ewha-18278 free base
CAS Number:1270084-92-8
Formula:C17H17N3O
M.w.:279.34
DMSO (mg/mL)Max Solubility:56
DMSO (mM)Max Solubility:200.47
Form:free base
SMILES:CCCC1=C(NN(C1=O)C2=CC=CC=N2)C3=CC=CC=C3
ALogP:2.994
Target:CCR,Interleukins,NADPH-oxidase,TNF-alpha
Pathway:Immunology & Inflammation
Information:Isuzinaxib (APX-115 free base, Ewha-18278 free base) is a potent, orally active inhibitor of pan NADPH oxidase (pan-Nox) with Ki of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base (Ewha-18278 free base) significantly suppresses the expression of inflammatory molecules including MCP-1/CCL2, IL-6, and TNFα in the diabetic kidney.
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